“‘I didn’t know!’ Dean continued mournfully, turning his gaze up imploringly at Heaven as if to ask how God could be so cruel as to inflict such pain. ‘I didn’t realize all these years that having unprotected sex with strippers could lead to my penis becoming a toxic injection of gonorrhea, chlamydia, syphilis, herpes and genital warts! I didn’t realize that Castiel lacked the appropriate human antibodies to deal with such infections!’
Overcome with guilt, Dean finally broke down in tears, and held out his arms to seek comfort and forgiveness.
'Don’t touch me,' Sam said.”